The new Librem laptops available for purchase with Monero offer an option to add a QubesOS operating system to any order. For Monero use exclusively, what are the security differences between PureOS and QubesOS?
In general, QubesOS offers greater security than PureOS. With QubesOS, programs are run in their own virtualized environment. This could offer greater protection if the computer was infected by a malicious program. Here's a good summary comment.
Note that you can install QubesOS on a Librem device with any USB. You do not necessarily need to buy the USB stick from Librem directly.