Another option is using a symbolic link, in Windows it's done with the mklink
command:
First make sure monero gui (and daemon) are stopped.
Move the lmdb folder from C:\ProgramData\bitmoneroC:\ProgramData\bitmonero
to its new destination (here D:\Monero\Blockchain).
(might work with the whole bitmonero folder moved and a bitmonero link in ProgramData, not tested this way as i don't mind the few MBs occupied by the log and p2pstate.bin on my SSD)
Open a command-line with administrator rights then:
CD /D C:\ProgramData\bitmonero
MKLINK /D lmdb D:\Monero\Blockchain\lmdb
This way you don't have to change any configuration / scripts or add parameters into shortcuts, as all programs see it as if the blockchain was still in its default location.